Yes. Hard Reboots are for established series who expand across many different mediums. Reboots for comics make sense, there are comics, movies, shows, games, that all contribute to a shared IP, but each might have an independent 'universe'. Mass Effect has some comics and books sure, but it is a video game first and foremost. A hard reboot is silly, at that point just make a new IP, it will work better. The move to Andromeda is, in some sense, a 'soft' reboot, which makes sense in the context of ME.
The Trilogy pretty much nullifies any ability to set a game within the next thousand years in the Milky Way, so there are a few choices.
1) Canonize an ending to create a static universe from which ME4 can be launched. BAD IDEA
2) Prequels - Play as a Krogan during the Rachni Wars, a Turian during the Krogan rebellion, a Prothean at the onset of their cycles end. These would work, and I would love to see something like this, but its issues are a forced non-human protagonist, which is a huge cost to sales.
3) Distant future - go so far into the future that ME3s ending is irrelevent. An ok choice, not my preference.
4) Contemporary timeline but different setting - Either some section of the Milky Way that is left out of the Mass Relay Network and is thus isolated from the after effects of ME3, or a different galaxy.
In my opinion #4 is the best because it can keep all the themes, all the technology, the racial histories and interactions, yet introduce new themes and new races (the native Andromedons) while still maintaining the Mass Effect feel.