The other issue with physical disabilities, like Joker's brittle bones, is that many of them should have been eliminated in the Mass Effect universe. Blindness for example, should be a thing of the past in a universe where something like the Lazarus Project exists. We know that synthetic eyes are a thing as well, because the Illusive Man has them.
Synthetic eyes wouldn't help much if there was something wrong with your occiptal lobe. Then again they got Shepard's brain to work after they floated around vacuum for a bit. Then again that was exorbitantly expensive. And there's always gonna be poor families or colonists that simply don't have access to gene therapy/screening.
Anyway, speaking to the OPs topic here: I really feel like people with disabilities have gotten the short end of the stick recently. There was (and is) feminism, which gave them voice and infinitely better representation. There was (and is) groups and There was and is the LGBT movement which is doing the same thing for people of different sexual orientations. I don't know if the anti 'PC' group has been growing per se, but the rise of Trump and his rhetoric make me think they're not exactly quiescent.
So what you wind up getting atm when you bring it up is disgust, exasperation, a sort of boggled amusement and/or outright rejection. There's this sense of the person suggesting it cannot POSSIBLY be serious, that the very topic is a joke. Now I haven't been around long enough to really know whether that was around at the beginning of feminism but I know I've seen it when someone suggests men should be able to marry each other and have a family or a transgender person use the correct bathroom. It's treated as ludicrous cuz no one wants to spend time thinking about it.
And what bothers me the most about it is the fact that I get the impression that this dismissive attitude occasionally comes from the groups that have and often still are exposed to the same kind of treatment. That's kinda shitty.
Q: Should we have women in our games fulfilling an array of roles as wide as men?
A: Uh, obviously?
Q: Should we have people of different races in our game?
A: Duh bruh.
Q: Should we have different sexualities?
A: Yeah, sure.
Q: Should we have people with disabilities in some (not necessarily combat) capacity?
A: Okay now you're just being silly.
I don't get it.