Memories, that's what count in a game like in a film or any art form...somethink that stick inside us for the rest of our life, and something original like a particular body type will stick in our mind much more that a standard body build, so I always encourage to focus on uniqueness...would that be body types or dialogues, or stories etc...
A small example and time inexpensive...a hand with one of the finger cut off...is a minor detail but easy to implement and could be the occasion to create a little story around that...I perfectly know about technology and how that finger could be replaced easily, but I think there also could be a million reasons why the finger is not replaced...fantasy comes first, but of course the world created must have a cohesive built...I think it is more realistic actually if there are such differences....have you ever took a walk in a city? I have never seen perfect bodies around, everyone has such amazing and inspiring uniqueness....I think it make more sense depict this in a game...I know it is not easy, but I just point the right way...at least in my possibly faulty opinion...
Cheers!