The MEU is fertile ground for any type of story or narrative. I wish they'd steer away from the trilogy template for the foreseeable future. Just tell standalone stories and jump around the established timeline.
Maybe go back to the Milky Way pre-Reaper Invasion, play as a space pirate in a rag-tag crew set in the familiar universe we know and love (possibly seeing places we've only heard about or seen in passing but have never truly been able to explore for ourselves), or a C-Sec officer forced to go undercover in order to take down a crime syndicate that has its ties from the Presidium to the seedy underbelly of the Wards in a game set solely on the Citadel....
As for Andromeda, I hope they get a lot more weird and different. They gotta change up the narrative. Being a cosmic savior is tired. I'm bored with being judge, jury and executioner of the entire galaxy. Time for something new.