When I saw this thread, I was expecting it to be about a storyline revolving around a society within Andromeda where biotics rule over non-biotics, similar to how force users rule over non-force users in The Empire from SWTOR. I'd be down with that. Maybe they could some super biotics. Hell, the idea of there being some ultra powerful biotics being worshipped as gods by a group of people would be pretty fascinating.
Biotics may just be Sci Fi mages, but a storyline about biotics ruling over a non-biotic underclass wouldn't make as much sense as similar stories in the fantasy genre. Technology would be a huge equalizer, and being able to throw things with your mind isn't all that impressive in a universe where modern firearms exist that can kill from 500 meters out. A small biotic minority establishing themselves as a ruling aristocracy through force is just not believable.
The only way that sort of story could work is with a new alien species that has a religion that reveres biotics. Superstition could be used to explain a biotic ruling class, but not force or intimidation. Human biotics in ME:A establishing themselves as a ruling class over a non-biotic majority that possesses modern weapons, would not be plausible at all.