I like my characters going through some sort of change in between, or characters that are a mix of the two. Redemption arc is great, and I have a character planned that's pure Paragon in the beginning, but will learn that being nice isn't always the best way to achieve certain things.
I'd say go for it. A little over a year ago I also was reluctant to play anything else than Paragon, let alone letting people die, then I gave my first more Renegadey character a chance - she disliked aliens and was distrustful of them (Mindoir past) and was a mission first type, and there were lots of casualties, but I came to love her and that run. Because she changed along the way and was more accepting of aliens in the end, even friends with some. The scenes with Garrus, Liara, Tali and Javik at the end were pretty amazing because of that. That was a really rewarding experience 
I don't want to play pure Renegade though because there are some really stupid and dickish options.
Your idea sounds good. Treat the people you like with respect, be a jerk to others, sounds like a fun time! My current Shepard was a naughty little flirty Paragon in ME1 drooling after most women, and he could also be a jerk to people he didn't like. He finally fell in love in ME2, became a (maybe) better person and also grew very dear to my heart, didn't think he would 
Oh, and another recommendation would be to actually ignore the interrupts, or at least largely. As tempting as it is to take interrupts, I had a good time trying that out. Also you could try and play someone neutral as well, you'll hear lots of dialogue that's great too, instead of just always picking the "I win" colours 