Like others have said, I'd like to see renegade responses return to a more pro human outlook than what they became in ME2/ME3. This is probably more likely since humanity are refugees in a new galaxy looking for a home, so I'm optimistic.
I would say it does make some sense in the latter two games. You are no longer the newbie on the block simply espousing pro human views to the galactic community who looks down on you, but must gather allies to your cause to fight for you. While a pro human Shepard would be interesting I can see why it was done away with a little in the writing.
Instead Bioware moved to the interrupt system. Here you are not making statements, but usually taking action. Again, like others have said I've never viewed ME3's renegade actions as more psychopathic than ME2. They are actions with a goal in mind of getting the job done, not sadistic violence for the sake of pleasure.
In the shooting Mordin example, I couldn't pull the trigger in my main Shepard's first playthough the scene was handled so well, Shepard can try to stall and then talk Mordin out of releasing the cure. At the end of the conversation Mordin says that he understands what Shepard's goals are but does not support them and the Shepard should do what he must. Mordin then says he will do what he must and heads for the tower.
During this entire conversation Shepard can state that he will stop Mordin, no matter the cost. That cost is Mordin's life, one that Shepard can be willing to pay. The interrupts are supposed to be decisive actions. I'd say that this is a huge one in the game, one of the most important even. A lot hangs in the balance of Shepard pulling that trigger or not. Maybe it's just me, but I don't see how that is more sadistic than pushing a merc out of skyscraper Shepard was talking to.
I do hope the interrupt system returns, I've never minded the whole paragon/renegade scale myself though. I'd just like it to be brought up more in game. It affected some auto dialogue and there are two possible types of the control ending based on the ratio of paragon or renegade. But I also like a way of keeping track of how my character is behaving overall. If Andromeda could expand on that some it'd be great. Possibly making it non binary would be interesting like suggested would be a better system.