Destroy. When you wake up on the SR-1, and tell Chakwas about your dreams, your first reaction is "We have to stop them. We have to destroy them before they destroy us."
Anderson wants you to Destroy.
The Illusive Man wants to Control - but he is gone, indoctrinated.
Saren wants to Synthesize - his original intention to live alongside the Reapers when the Harvest is complete. But he, too, can not resist them...
The two who represent Control and Synthesis are firmly under Reapers' control. Anderson and Shepard, however, are not. Thus Destroy is the only true option.
And Refuse should die in a furnace.