Hm...
Well:
- again: No space battles
only farm-machinery (it's what the new Mako looks like IMHO...just don't like it!) to drive around on planets 
- stupid consolised dialogue-wheel again...they'll never learn (or: Stop fixing what was never broken in RPGs)
- Ryder? Don't like the name, but I can probably live with it (as long as not everybody calls me that...got annoyed being called "Shepard" all the time, too)
- Ryder-Family? Stop copying from Bethesda
(it's not working for them, what makes you guys think you can do better? What makes you think we WANT a family-story (well: I at least don't, I have a family (parents and sister - I won't get married and have children!) and to be honest I sometimes wish I did not)?)
- Good thing they fixed that relationship system (if - and I stress: IF - it works as advertised...remember they said ME3 has a ton of different endings and tons of player choices etc.!)
- Good thing they are - kind of - discarding ME3!
- hundreds of years? Was that damned Ark that slow (if so: trash that heap of junk ^^) or a generation ship even???
- what's the main characters family (parents, sister etc.) doing on the Ark? (in an desperate situation (as in: annihilation might be inevitable!) only the best an brightest would (and should) be sent/saved...which IMHO doesn't include giving their families a free boarding passes - call it "mean" but it's best for all the species involved to only send their best to make a fresh start!)
- oh, nice: Heroe's journey as method of story telling (I like that one - if they really let me shape my character and don't have AUTO-DIALOGUE and if they keep my decisions relevant (and don't discard them like in ME3 - Genophage data (why did Mordin have to die despite having kept the ****** DATA?), Quarians at war (told them not to damned!) etc.)
- re-explained is ok (as long as there's new tech-goodies (we've already seen that jump-pack (not: Jet-Pack, as it can't sustain flight for very long), so there's hope!)) as long as they don't force it on you 
- the Mako did "crazy stuff"? Not mine (it's got a damned-mass-effect-generator inside, so that explains why the laws of physics for it are bent a little IMHO!)...so they turned the vehicle that was at least partly cool into just a normal APC (no more Jump-Jets on the Mako? - Damned, I love to use them to dodge missiles etc.!)
- I'd like to know if the Ark is a hub (or if it was stripped...hope not, because that thing looks great and if it's armed and armored calling it in might make our job easier ^^)
- What? Race car "jokeys" helped make a TANK? (isn't that something above their weight class/outside of what they normally do?)
- "The Tempest has a lot to offer" - I'd hope so (more ship upgrades etc. would be nice...being able to name the ship would be something, too (as much as I liked the Normandy (SR2 - didn't like the first version as much!) itself, I could have done with another name!)
- sadly: Only human protagonist (despite the new scenario being PERFECT for having an alien protagonist (after all: We all, from humans, to turians, to asari, to krogans etc. are new in Andromeda, so we'd have to work together or face annihilation - AGAIN!))
- homosexual/lesbian-romance is fine, but what about say: A stable threesome (those do exist, they might be rare, but they exist...on the other hand: elite soldiers are also rare and we are one, again!) or an open relationship etc. (not the typical relationship)?
Well, all in all: Not bad 