I don't see why. As digital beings, they could conceivably create physical avatars that they can control, either as a companion character or as an enemy faction. On top of that, we could also have the opportunity to explore their own world through whatever interface, similar to the pod that accesses the consensus in ME3. I guess the only problem is that they could feel like geth 2.0, but you can get around that by emphasizing on their individuality, and maybe the history of their species that precedes their transition to digital beings.
This. I can see the potential benefits of shedding our limited bodies one day and uploading our consciousness to heavily protected future versions of servers. That's assuming we can ever get a grasp on what consciousness actually is, separate it from our physical bodies while still retaining ourselves and not a copy of ourselves. But we 're talking Mass Effect scifi fantasy so I'm rolling with the idea.
Imagine not having to deal with the limitations of our bodies. Our virtual world could mimic those sensations we want to experience while limiting unpleasant aspects of having a body. No maintenance, aches and pains, disease. We'd create limitless beautiful virtual spaces to inhabit all while changing virtual form as easily as we change clothes. When we want to experience the physical world, we select a body to control and off we go. Or perhaps we want to control something more durable than a body and slip into a ship to explore a nebula or something. What if our lover were simultaneously in bed with us and a ship somewhere orbiting a sun? How would we feel knowing we weren't it's sole focus? It would be fascinating and I would love to see the ME writers actually explore this idea.