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So, by staying in the MW galaxy and hiding in a hole somewhere, you believe the Reapers won't find you? You may be willing to take this high risk of human erasure but I don't.
From a development point of view, going to Andromeda and starting fresh, is the better idea. Besides, people easily forget that Shep was a three game series, period. Another Mass Effect game needs to start off in a different direction.
You misunderstand - fleeing the Reapers is the only conceivable reason to leave the MW that I don't find absolutely ludicrous.
Mind you - it's still silly. The Reapers don't wipe out pre-industrial civilizations in the MW - they target the Citadel species only. There are a hundred billion stars in the MW... and even some Eden worlds were known about that aren't yet colonized. Seeding humanity without tech (but with the knowledge) onto those words to ensure the survival of the species would have been a no brainer.
Fooling the Reapers takes only forgoing the use of their tech.
But - since we ARE going to Andromeda - for me, it has to at least be because of the galactic threat and not just "wonder and awe and humanity!"