Even those elements were mostly explained as various biological phenomena, it was was still rather fantastic, but the scientific fluff was mostly enough
to keep it from sounding like actual space magic. (connecting nerve systems, pheromones, spores, biological quantum entanglement, etc.)
Since ME2 however, those considerations to the theme and careful handling of the lore were mostly thrown out of the airlock and replaced by comic-book logic. (Dominate, Reave, "appropriate attire" for space walks, the thermal clip logic, etc. - in addition to the stuff mentioned above.)
ME3 was slightly better in this regard, but still not as good as ME1 when it came to the theme and feeling of the universe.
The scientific fluff kept it from sounding like space magic only if you didn't know anything about the words they picked at random during the rushed Wikipedia search they ran to add a science gloss to their space magic. It's tossed salad gibberish. And that's without getting into the actual science they didn't even need to butcher they they completely butchered anyway - like basically all of biology, or AI and machine learning, and so on.
Mass Effect 1 is a combination of ignorance, Google, and space magic. Interstellar, a movie that was originally grounded in physics, branched into non sequitur and (borderline) space magic as they transitioned from physics to the screen (e.g. the changes they made to gargantuan to keep people from being confused at there being lots of black holes).
Mass Effect 1 isn't grounded. It's star wars. The science gibberish they use is just the same kind of nonsense as midichlorians. Space magic doesn't stop being space magic because some of the time you use science sounding words. And they don't even bother with fake science for the biggest offenders of space magic - like the asari mind powers, the Thorian memory mulch, it's ability to clone sapient plant people (!!!), the Cypher itself, the very operation of the beacons...
The list goes on. Mass Effect 1 tried to get one thing right: a method of FTL travel that wasn't a complete farce on its face and a way of creating the force without calling it the force.