Tsk, tsk, tsk... I leave for a few hours and the whole thread goes to... well wherever it's gone with floating "stuff" and ethernet condoms... *crosses arms and shakes head* ...
Now, I don't know about you, but Joker really doesn't strike me as the aged virgin type

As such I'm guessing he's worked out an idea or two of how to go about being intimate without too much injury.
That being said, I'm good with Joker not being an LI as long as he's still around. I'm also good with him being an LI, whether he's magically cured or not... as I said, he can probably fill Shep. in on how to go about it without major injuries and frankly, if an organization can figure out how to bring someone back from dead (it being apparently only a matter of money) I don't see it as such a stretch they could work something out to remedy the bone situation (seems fairly minor in comparison given that Shep. was probably a mostly burned husk of nothing much by the time she hit planetside), just have to figure out who Shep. needs to kill/bribe/charm to get the necessary funds going in the proper labs and channels
Anyhoo, as long as there's Joker in ME3, I'm good