Hiero Glyph wrote...
Sadly the videos showed nothing worth noting. For the most part you spammed Singularity and always had one memeber of your squad using the Incisor. I thought you were trying to show the differences between the pistols?
The Hand Cannon has ammo issues but can still quickly put down enemies from almost any distance. The damage is often overkill as it will typically damage 33% of the enemy's health/armor per shot. In some cases using a 4th shot is simply wasteful as you only need to remove a fraction of their total health/armor. In this case you should not waste the shot from the Hand Cannon.
If you are using Cryo ammo then the Predator is indeed better as the goal is to lay status effects and not deal direct damage. In this case the added ammo is perfect. For dealing with armor the Hand Cannon still wins as it will strip away the defense faster than the Predator. Once the armor is gone you should alter your strategy and either switch to another weapon or use an ability. In your case it would be logical to throw Singularity, Hand Cannon the armor away and then watch the enemy get tossed.
Both pistols have their uses but you showed nothing of note in your video as you were too busy spamming Singularity and Warp and having a squadmate use the Incisor. Next time provide a situation where you can single out an enemy, pin them with Singularity and see which pistol works better against armor/health.
I tried to show how ineffective the hand cannon was against barriered enemies. I also was trying to show how, when put in a situation where you cannot get access to more ammo, the weakness of the hand cannon really shows. I did spam my abilities, but thats because I was hoping to avoid dying

My first vid has more of what your looking for. For right now, I'm just trying to recreate gameplay situations, not necessarily a lab type situation. I can definitely do that, but I felt like it would be cheating a little bit to divorce the pistols from a real gameplay type situation.
For a straight damage comparison, the hand cannon wins hands down, but I think more factors go into a weapon's qualifier as "better" than a simple damage comparison. I think if that's what your looking for, there is a chart on Gamefaqs that has straight damage comparisons.